Has anyone dealt with muscle protein synthesis window?

Dr.PainCLE said:

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

Worth separating that from protein intake, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

mike.trainer_LA said:

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Adding it to my notes with a link back to this thread.

Dr.PainCLE said:

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

Dr.BariatricHTX said:

I lifted three times a week throughout and still lost lean mass.

Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Lumbar spine T-score: -0.12 → -0.8 (stable to slightly improved)
Femoral neck T-score: -0.9 → -0.9 (stable)

No significant bone loss despite 74 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.

Moderator note: a couple of off-topic posts removed. Carry on.