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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — 6 month update Page 3

MASH resolution without worsening fibrosis — 6 month update

patPC_UT Mon, Apr 20, 2026 at 4:13 PM 11 replies 565 viewsPage 3 of 3
CarlaRPh_TPA
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Apr 21, 2026 at 4:33 PM#11
JenPlateau said:
It is worth asking what the claim would look like if it were false.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

I would rather be corrected than agreed with, if it comes to it.

40 13FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 37 others
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Dr.LeslieOBGYN
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Apr 22, 2026 at 10:39 AM#12
pat_auckland said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

41 14FranDenver, Dr.BariatricHTX, LindaRN_retired and 38 others
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wei_SG
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Apr 23, 2026 at 4:45 AM#13
JenPlateau said:
It is worth asking what the claim would look like if it were false.

Pushing back on JenPlateau here. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

42 15Dr.MetabolicMD, RetaRick_CA, JenPlateau and 39 others
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BiostatsBrad
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Apr 23, 2026 at 10:51 PM#14

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

43 16james_edin, FranDenver, Dr.BariatricHTX and 40 others
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Admin
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Apr 24, 2026 at 4:58 PM#15

Moderator note: a couple of off-topic posts removed. Report rather than reply if it drifts again.

44 17PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 41 others
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