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ForumsMASH / Liver DiseaseDoctor said my fatty liver is GONE - I literally cried Page 2

Doctor said my fatty liver is GONE - I literally cried

DerekSJ_a1c Tue, May 19, 2026 at 9:11 AM 22 replies 718 viewsPage 2 of 5
Dr.ObesityLA
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May 20, 2026 at 6:12 PM#6
Dr.SportsMedIN said:
Liver ultrasound comparison for liver and MASH: my hepatologist ordered serial ultrasounds to track NAFLD regression.

Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD). After 7 months on GLP-1 therapy:

MarkerBaselineCurrentNormal Range
ALT67297-56 U/L
AST552310-40 U/L
GGT72359-48 U/L
ALP1027944-147 U/L

FibroScan also improved — liver stiffness from 9.5 kPa to 6.2 kPa. The evidence for GLP-1 agonists in NAFLD/NASH is very promising.

44 14zoe_NC, Dr.ObesityLA, NurseKim_ATL and 41 others
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wendy_avl
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May 21, 2026 at 7:24 AM#7
DerekSJ_a1c said:
Fatty liver on an incidental scan two years ago and nobody followed it up.

ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase 3 ATTAIN trial. NASH resolution was achieved in ~60% of patients[1].

This is relevant to liver and MASH because survodutide's glucagon agonism specifically targets hepatic lipid metabolism — making it potentially the best-in-class agent for NASH/MAFLD comorbid with obesity.

References:
[1] Sanyal AJ, et al. N Engl J Med. 2024.
43 13DoseLogDan, SleepFixSam, PurityPaulOR and 40 others
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Dr.GutHealth
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May 21, 2026 at 8:36 PM#8
Dr.ObesityLA said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

Adding the part of the answer the thread has not reached. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

42 12jennifer_SEA, tyler_CSCS, VanRx_Mike and 39 others
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raj_cambridge
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May 22, 2026 at 9:48 AM#9

Following on from TrialTracker_MD — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

41 11PharmHunterJen, TomTeleRx, DoseLogDan and 38 others
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DerekSJ_a1c
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May 25, 2026 at 1:12 AM#10

Closing the loop on my own question.

Resolved, and the thing that resolved it was the least interesting suggestion in the thread. Writing that down for the next person who wants the interesting answer.

Last edited: May 25, 2026 at 6:12 AM
31 4AttorneyGrant, DebRD_ATL, KristenIndy and 28 others
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