Alcohol + MASH + GLP-1 — can semaglutide help alcohol-related liver disease?

Dr.NephBHM_UK said:

Dr.AddMedPHL said: ...but the FDA says semaglutide...

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

ChrisMacros said:

Agreed, and ALT falling is not the same as fibrosis improving.

This is where I part company with the consensus forming above. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

That is the short version; the long version is somebody else's post.

ChrisMacros said:

Agreed, and ALT falling is not the same as fibrosis improving.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

ChrisMacros said:

Agreed, and ALT falling is not the same as fibrosis improving.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.