traveltech_sara said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Coming at traveltech_sara’s question from a different direction. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.