My liver enzyme journey — ALT from 98 to 19 on semaglutide

One thing that is still open after andrew_nyc’s answer:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

lisa_labSD said:

If you are going to change something, change one thing and give it long enough to express itself.

Pushing back on lisa_labSD here. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

lisa_labSD said:

If you are going to change something, change one thing and give it long enough to express itself.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

lisa_labSD said:

If you are going to change something, change one thing and give it long enough to express itself.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

Reporting back.

Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me. I was escalating because the number was available, not because I had stopped responding.