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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide and exercise performance — VO2max and endurance data Page 5

Semaglutide and exercise performance — VO2max and endurance data

RunnerRach Sun, Apr 5, 2026 at 11:50 AM 23 replies 717 viewsPage 5 of 5
AttorneyGrant
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Apr 25, 2026 at 12:35 PM#21
emily_PDX said:
No disagreement, though the timescale matters more than the mechanism here.

Same experience, arrived at from the opposite direction.

36 9Dr.SleepRoch, laura_annarbor, JenMemphis and 33 others
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MikeKY_noInsulin
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May 3, 2026 at 7:25 AM#22
emily_PDX said:
No disagreement, though the timescale matters more than the mechanism here.

Adding the part of the answer the thread has not reached. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

37 10hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 34 others
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PeptideChemSF
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May 11, 2026 at 2:10 AM#23

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

38 11FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 35 others
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tane_welly
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May 18, 2026 at 8:51 PM#24

One thing that is still open after emily_PDX’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

39 12marco_milano, pam_columbus, nick_SD_fit and 36 others
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Dr.MetabolicMD
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May 26, 2026 at 3:27 PM#25
PeptideChemSF said:
Keep the original post as written when you update it, and add the correction underneath.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

40 13GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 37 others
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