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ForumsSemaglutide (Ozempic / Wegovy)Sema fatigue at month 6 — caloric deficit mitigation strategies Page 2

Sema fatigue at month 6 — caloric deficit mitigation strategies

Dr.NutriCornell Wed, May 6, 2026 at 8:51 AM 6 replies 473 viewsPage 2 of 2
LabKate
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May 6, 2026 at 1:44 PM#6

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

20 15JenMemphis, pat_auckland, Dr.GastroMayo and 17 others
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TomTeleRx
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May 6, 2026 at 3:39 PM#7

One thing that is still open after Dr.KarenChen’s answer:

Was that from a primary source or from a summary of one?

19 14bri_stats, pete_manc_UK, anna.melb_AU and 16 others
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Dr.ObesityMed
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May 6, 2026 at 5:34 PM#8
LabKate said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Coming at LabKate’s question from a different direction. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: May 6, 2026 at 11:34 PM
18 13SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 15 others
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Dr.NutriCornell
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May 6, 2026 at 7:29 PM#9

Reporting back.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

Last edited: May 6, 2026 at 9:29 PM
17 12JenMemphis, pat_auckland, Dr.GastroMayo and 14 others
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MaxMetOK
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May 7, 2026 at 4:41 AM#10
Dr.ObesityMed said:
Start from the measurement rather than the conclusion.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Happy to go further on any of that.

25 23PurityPaulOR, MaxMetOK, MounjBrad and 22 others
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