Switching from Ozempic to Wegovy — same drug, different experience?

MASHdoc_SA said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at MASHdoc_SA’s question from a different direction. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Following on from MASHdoc_SA — and this may be the naive question:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

DataDave said:

Keep the original post as written when you update it, and add the correction underneath.

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

DataDave said:

Keep the original post as written when you update it, and add the correction underneath.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.