hans_munich said:A1cHero_PHX said: ...but the FDA says semaglutide...
Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.
PharmacoVig_BOS said:A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator.
Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.
PharmacoVig_BOS said:A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator.
Thank you for spelling out the reasoning rather than just the conclusion.
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Browse GL BiochemAdding the clinical framing, because it changes how the question reads. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Report rather than reply if it drifts again.