julia.endo said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
hans_munich said:The mechanism is more central than most summaries suggest.
That reframing is the part I needed. Adding it to my notes with a link back to this thread.
julia.endo said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
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Browse GL BiochemOne concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.