JenPlateau said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.
From the other side of the consultation, briefly. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
PedsEndoPhilly said:I want to add the drug interaction perspective on the pharmacology.
I read this differently from PedsEndoPhilly, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
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Browse GL BiochemAdding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
Happy to go further on any of that.