Dr.PathRoch said:The shortage clause is the answer to the second question and it is a subtraction rather than an addition.
True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.
denise_HTX said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
Dr.PathRoch said:The shortage clause is the answer to the second question and it is a subtraction rather than an addition.
I read this differently from Dr.PathRoch, on substance rather than tone. A research-chemical supplier selling lyophilised powder labelled research use only is not compounding and is not claiming to. It is a different legal universe with no pharmacy oversight, no patient relationship and no content guarantee, and conflating the two in these threads helps nobody.
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Browse GL BiochemOne concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.