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ForumsRetatrutide & Triple AgonistsRetatrutide Phase 2 dose-response analysis — need advice Page 5

Retatrutide Phase 2 dose-response analysis — need advice

SarahChen_PharmD Wed, Sep 11, 2024 at 8:40 PM 55 replies 2,123 viewsPage 5 of 11
KevinCompounds
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Sep 13, 2024 at 8:36 PM#21

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

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DebRD_ATL
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Sep 14, 2024 at 7:52 AM#22
KevinCompounds said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same experience, arrived at from the opposite direction.

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ricardo_MIA
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Sep 14, 2024 at 7:08 PM#23
KevinCompounds said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

There is a second half to this that has not been said yet. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.

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stefan_berlin
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Sep 15, 2024 at 6:24 AM#24

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Sep 15, 2024 at 9:24 AM
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PharmacoVig_BOS
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Sep 15, 2024 at 5:40 PM#25

Following on from KevinCompounds — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

Last edited: Sep 15, 2024 at 8:40 PM
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