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ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? — anyone have experience? Page 2

Will reta make sema and tirz obsolete? — anyone have experience?

newstart_MO Sat, Oct 19, 2024 at 12:40 AM 20 replies 1,973 viewsPage 2 of 4
Dr.AddMedPHL
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Oct 19, 2024 at 9:34 AM#6

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

1 21FitDadDave
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nick_newbie
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Oct 19, 2024 at 1:04 PM#7

A narrower follow-up, since the general answer is now clear:

Why adding glucagon agonism to an anti-obesity drug is not self-defeating, given that glucagon raises blood glucose?

50 20dan_philly, MeganSA_TX, LarryQC_SD and 47 others
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julia.endo
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Oct 19, 2024 at 4:34 PM#8
Dr.AddMedPHL said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Adding the part of the answer the thread has not reached. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

I would rather be corrected than agreed with, if it comes to it.

49 19hans_munich, jason_sac26, chris_chi24 and 46 others
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newstart_MO
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Oct 19, 2024 at 8:04 PM#9

Closing the loop on my own question.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

Last edited: Oct 20, 2024 at 2:04 AM
48 18TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 45 others
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roxy_nash
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Oct 20, 2024 at 12:52 PM#10
julia.endo said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

44 17kim_atl_prep, sarah_TO, wendy_avl and 41 others
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