Dr.PathRoch said:It helps to ask what evidence would change your mind before you look at any.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
Dr.CardioMD said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
This answered a question I did not know how to ask.
Dr.PathRoch said:It helps to ask what evidence would change your mind before you look at any.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.
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Browse GL BiochemAdding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.