TRIUMPH-2 obesity without diabetes — anyone have experience?

EndoResFellow said:

Worth answering the question that was asked rather than the one behind it.

Same pattern here, and in the same order. I had assumed I was the exception until I read this.

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Dr.EndoIndy said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Second this. The detail I would add is minor and it is already implied above.

Dr.EndoIndy said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Coming at Dr.EndoIndy’s question from a different direction. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.