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ForumsLab Results & BiomarkersUric acid trends on GLP-1 — 6 month update

Uric acid trends on GLP-1 — 6 month update

Dr.KarenChen Fri, Dec 6, 2024 at 4:52 AM 16 replies 1,710 viewsPage 1 of 4
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Dr.KarenChen
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Dec 6, 2024 at 4:52 AM#1

I got a full panel before starting and a repeat at three months, and the second one is more useful than the first purely because I now have something to compare against.

What I actually want to know is how often to repeat it, because quarterly seems to be the convention and I cannot find the reasoning.

Practical detail welcome, however dull — the duller the better.

48 18julia.endo, JessicaM_2024, TomFromTexas and 45 others
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PharmD_Rodriguez
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Dec 6, 2024 at 5:27 AM#2

Taking the question as asked, rather than the general version of it. The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value. One out-of-range result in isolation generates anxiety and unnecessary tests; the same result next to the trend and the rest of the panel usually generates a shrug.

Last edited: Dec 6, 2024 at 10:27 AM
47 17TinaHashiRN, robert_kc, dan_philly and 44 others
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PedsEndoPhilly
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Dec 6, 2024 at 6:02 AM#3
PharmD_Rodriguez said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Agreeing with PharmD_Rodriguez, and the qualification matters more than the agreement. One addition: if the lab changes analytical platform between your draws, the comparison breaks and nobody tells you. It is worth asking when a value moves inexplicably.

46 16jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 43 others
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anna.melb_AU
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Dec 6, 2024 at 6:37 AM#4
Dr.KarenChen said:
I got a full panel before starting and a repeat at three months, and the second one is more useful than the first purely because I now have something…

This matches mine closely enough to be worth saying so. Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c becomes informative again, since it reflects about three months of glycaemia. After the first year, and once doses are stable, annual is reasonable unless something specific is being followed.

Happy to go further on any of that.

45 15tammy_FL, Dr.LipidDallas, alex_tucson and 42 others
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Dr.NutriCornell
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Dec 6, 2024 at 9:54 AM#5

Clinical perspective, offered as context rather than as advice.

Shot day Thursday report relevant to baseline bloodwork:

Week 36. Currently on 5mg. Down 22 lbs from starting weight of 234 lbs.

This week's observations: Energy levels excellent, zero nausea.

Labs due next week — looking forward to seeing the metabolic panel. I'll post results in the Lab Results section when they come in.

Last edited: Dec 6, 2024 at 11:54 AM
44 14pat_auckland, Dr.GastroMayo, JakeBK_lifts and 41 others
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