From the other side of the consultation, briefly. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
wendy_avl said:Practical: unopened, refrigerated at 2 to 8°C; in use, refrigerated and used within the preservative-limited window; never frozen; and a visual check…
Genuinely useful, thank you. I had the facts and not the framework.
Adding the clinical framing, because it changes how the question reads. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.
Worth separating that from storage and cold chain, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
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Browse GL BiochemCarlaRPh_TPA said:Start from the measurement rather than the conclusion.
Can confirm the pattern CarlaRPh_TPA describes. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.