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ForumsRetatrutide & Triple AgonistsGlucagon receptor agonism and hepatic lipid oxidation — need advice Page 3

Glucagon receptor agonism and hepatic lipid oxidation — need advice

mike_mod Sat, Aug 16, 2025 at 1:49 PM 30 replies 1,870 viewsPage 3 of 6
LabKate
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Aug 17, 2025 at 8:30 AM#11
Dr.NutriCornell said:
The mechanism and the magnitude are separate questions.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

7 5JenMemphis, pat_auckland, Dr.GastroMayo and 4 others
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tane_welly
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Wellington, NZ
Aug 17, 2025 at 9:17 PM#12
CryptoCarl said:
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

8 6carl_compliance, DanielChem_CHI, marco_milano and 5 others
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JenPlateau
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Aug 18, 2025 at 10:04 AM#13
Dr.NutriCornell said:
The mechanism and the magnitude are separate questions.

Pushing back on Dr.NutriCornell here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

9 7RunnerRach, TrialNerd_Beth, HPLC_Greg and 6 others
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Dr.AddMedPHL
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Aug 18, 2025 at 10:51 PM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

10 8TomFromTexas, mike.trainer_LA, sarah_nash92 and 7 others
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Admin
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Aug 19, 2025 at 11:37 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Report rather than reply if it drifts again.

11 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 8 others
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