🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersCholesterol dropped 80 points and my doc is shook — anyone have experience?

Cholesterol dropped 80 points and my doc is shook — anyone have experience?

nancy_portland Wed, Jul 2, 2025 at 9:52 AM 32 replies 1,521 viewsPage 1 of 7
This thread is more than 11 months old. Information may be outdated. Consider searching for more recent discussions.
nancy_portland
Member
345
1,567
Aug 2024
Portland, ME
Jul 2, 2025 at 9:52 AM#1

Putting this up for argument rather than for agreement. I have read it twice and I am still not certain what it supports.

ApoB is the more informative number and it is cheap. LDL-C estimates cholesterol mass in atherogenic particles; ApoB counts the particles, and it is particle count that tracks risk — which is why the two can disagree and why the disagreement is the clinically interesting case. Triglycerides fall substantially with weight loss and improved insulin sensitivity, HDL moves modestly, and LDL-C often barely moves at all, which surprises people who expected everything to improve together.

Where I think it is weakest: the comparator does most of the work in how this gets reported, and it is not the comparator most people think they are citing.

What would genuinely help is knowing whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories. Numbers rather than impressions, if you have them.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
3 23DebRD_ATL, KristenIndy, MarkLI_maint
Reply Quote Save Share Report
Dr.GastroMayo
VIP Member
2,345
13,456
Jan 2024
Mayo Clinic, MN
Jul 2, 2025 at 10:57 AM#2
nancy_portland said:
ApoB is the more informative number and it is cheap.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.2% to 7.7% over 13 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

2 22VendorMark, COA_Karl
Reply Quote Save Share Report
TirzTom
Senior Member
2,789
9,876
Feb 2024
Florida
Online
Jul 2, 2025 at 12:02 PM#3
nancy_portland said:
ApoB is the more informative number and it is cheap.

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

I would rather be corrected than agreed with, if it comes to it.

1 21Dr.EndoIndy
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
anders_CPH
Senior Member
1,567
7,234
Feb 2024
Copenhagen, DK
Jul 2, 2025 at 1:07 PM#4
TirzTom said:
Careful with treating an unchanged LDL-C as a failure.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1665965Particle count (more precise than LDL-C)
Small dense LDL60%29%Atherogenic pattern
Remnant cholesterol3714Triglyceride-rich lipoproteins
oxLDL7043Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

Last edited: Jul 2, 2025 at 5:07 PM
50 20BethLabQueen, ChrisMacros, KetoKyle and 47 others
Reply Quote Save Share Report
Dr.EndoIndy
Member
267
1,234
Oct 2024
Indianapolis, IN
Jul 2, 2025 at 7:21 PM#5
Dr.GastroMayo said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.2% to 7.7% over 13 months.

Same experience, arrived at from the opposite direction.

49 19SandraNC_45, Dr.EndoIndy, tom_AK and 46 others
Reply Quote Save Share Report
1237

Similar Threads

Optimal lab testing frequency on GLP-1 — evidence-based schedule5 replies
A1C from 7.2 to 5.1 — my bloodwork transformation19 replies
Thyroid function monitoring on GLP-1 — TSH and free T4 trends3 replies
Lipid panel improvements mega-thread — share your numbers19 replies
Liver enzymes trending down on GLP-1 — ALT/AST normalization17 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register