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ForumsRetatrutide & Triple AgonistsHas anyone dealt with glucagon-mediated thermogenesis on retatrutide? Page 2

Has anyone dealt with glucagon-mediated thermogenesis on retatrutide?

DoseLogDan Fri, Feb 13, 2026 at 11:14 PM 7 replies 870 viewsPage 2 of 2
jason_paloalto
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Feb 14, 2026 at 12:45 AM#6

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

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GenomicsKate
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Feb 14, 2026 at 1:20 AM#7

Following on from SleepDoc_PDX — and this may be the naive question:

Why adding glucagon agonism to an anti-obesity drug is not self-defeating, given that glucagon raises blood glucose?

Last edited: Feb 14, 2026 at 6:20 AM
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Dr.SurgeonPGH
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Feb 14, 2026 at 1:55 AM#8
jason_paloalto said:
Say what you would expect to see if you were wrong, before you look.

There is a second half to this that has not been said yet. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Feb 14, 2026 at 4:55 AM
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DoseLogDan
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Feb 14, 2026 at 2:30 AM#9

OP back with an update, since a thread like this is useless without one.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

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Admin
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Feb 14, 2026 at 5:17 AM#10
Dr.SurgeonPGH said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

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