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ForumsLab Results & BiomarkersCortisol and GLP-1 — need advice Page 8

Cortisol and GLP-1 — need advice

NurseLeah_Nash Mon, Feb 2, 2026 at 8:41 AM 43 replies 1,438 viewsPage 8 of 9
Dr.RaviCardio
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Feb 10, 2026 at 1:05 PM#36

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

17 15pete_manc_UK, anna.melb_AU, mark_tokyo and 14 others
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A1cHero_PHX
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Feb 10, 2026 at 10:29 PM#37

One thing that is still open after ingrid_STO’s answer:

What did you change at the same time, and can you separate the two now?

18 16KarenAZ_mom, zoe_NC, Dr.ObesityLA and 15 others
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labquiet_amy
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Feb 11, 2026 at 7:54 AM#38
Dr.RaviCardio said:
If you are going to change something, change one thing and give it long enough to express itself.

Pushing back on Dr.RaviCardio here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

19 17LibrarianMeg, bri_stats, pete_manc_UK and 16 others
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SallyK_inj
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Feb 11, 2026 at 5:19 PM#39
Dr.RaviCardio said:
If you are going to change something, change one thing and give it long enough to express itself.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

20 18tane_welly, Dr.PathRoch, mona_PHX and 17 others
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DataDave
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Feb 12, 2026 at 2:44 AM#40
Dr.RaviCardio said:
If you are going to change something, change one thing and give it long enough to express itself.

Genuinely useful, thank you. I had the facts and not the framework. Sending this to two other people who asked me the same thing last week.

Last edited: Feb 12, 2026 at 3:44 AM
42 15Dr.GutHealth, amsterdam_pete, LondonLisa and 39 others
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