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ForumsRetatrutide & Triple AgonistsTriple agonist side effect profile — what to expect from GCG addition Page 2

Triple agonist side effect profile — what to expect from GCG addition

Dr.GastroMayo Wed, May 6, 2026 at 6:24 AM 10 replies 603 viewsPage 2 of 2
BethLabQueen
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May 6, 2026 at 12:09 PM#6

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Last edited: May 6, 2026 at 1:09 PM
24 2maya_sedona, stefan_berlin, Dr.EM_Chicago and 21 others
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rachel_ABQ
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May 6, 2026 at 2:24 PM#7

One thing that is still open after james_edin’s answer:

Why adding glucagon agonism to an anti-obesity drug is not self-defeating, given that glucagon raises blood glucose?

Last edited: May 6, 2026 at 7:24 PM
25 3DadBodDave, AmyNC_wife, SkepticalSean and 22 others
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NurseAsh_DET
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May 6, 2026 at 4:39 PM#8
BethLabQueen said:
If you are going to change something, change one thing and give it long enough to express itself.

There is a second half to this that has not been said yet. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

26 4BrianDallas92, labquiet_amy, emily_PDX and 23 others
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Dr.GastroMayo
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May 6, 2026 at 6:54 PM#9

Closing the loop on my own question.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

Last edited: May 6, 2026 at 11:54 PM
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sarah_nash92
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May 7, 2026 at 5:43 AM#10
NurseAsh_DET said:
Worth answering the question that was asked rather than the one behind it.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Correct me if the detail matters more than I have assumed.

Last edited: May 7, 2026 at 11:43 AM
27 0KetoKyle, CanadaChris, ZaraB_AL and 24 others
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