carl_compliance said:Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…
Mine went the same way, slower.
A narrower follow-up, since the general answer is now clear:
How to read eGFR during rapid weight loss, given that creatinine depends on muscle mass and muscle mass is changing?
stefan_berlin said:Say what you would expect to see if you were wrong, before you look.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.
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View Resultsstefan_berlin said:Say what you would expect to see if you were wrong, before you look.
That is correct as far as it goes, and here is where it stops going. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.