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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsPatient preference: weekly injection vs potential monthly depot Page 2

Patient preference: weekly injection vs potential monthly depot

SteveThurs Thu, May 14, 2026 at 7:39 AM 10 replies 443 viewsPage 2 of 2
kate.chem
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May 14, 2026 at 9:03 AM#6
KevinCompounds said:
Start from the measurement rather than the conclusion.

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

12 15steve_okc, dave_SLC, FDA_TrackerJim and 9 others
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dave_SLC
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May 14, 2026 at 9:36 AM#7

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

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CarlaRPh_TPA
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May 14, 2026 at 10:09 AM#8
kate.chem said:
I would rather people stopped quoting the 24% as if it were a licensed outcome.

Coming at kate.chem’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

That is the short version; the long version is somebody else's post.

Last edited: May 14, 2026 at 2:09 PM
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B12Beth
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May 14, 2026 at 10:42 AM#9

One thing that is still open after tammy_FL’s answer:

What the phase 2 dropout pattern implies about how the phase 3 tolerability will read?

15 18marco_milano, pam_columbus, nick_SD_fit and 12 others
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SteveThurs
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May 14, 2026 at 1:20 PM#10

Reporting back.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

Last edited: May 14, 2026 at 5:20 PM
5 3TomTeleRx, DoseLogDan, SleepFixSam and 2 others
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