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ForumsClinical Trials & ResearchBimagrumab + semaglutide — my results so far Page 6

Bimagrumab + semaglutide — my results so far

MaxMetOK Fri, Jan 9, 2026 at 3:38 PM 32 replies 1,200 viewsPage 6 of 7
AmyNC_wife
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Jan 13, 2026 at 5:23 PM#26

Following on from GenomicsKate — and this may be the naive question:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

Last edited: Jan 13, 2026 at 6:23 PM
23 21JessicaM_2024, TomFromTexas, mike.trainer_LA and 20 others
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pete_RVA
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Jan 14, 2026 at 2:27 AM#27
quinn_sf said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

This is where I part company with the consensus forming above. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

24 22Dr.Martinez, mike_mod, SarahChen_PharmD and 21 others
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Dr.RenalNash
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Jan 14, 2026 at 11:31 AM#28
quinn_sf said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

25 23Dr.NutriCornell, pam_stl, wei_SG and 22 others
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VendorMark
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Jan 14, 2026 at 8:35 PM#29
quinn_sf said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

26 24Dr.PeteFamMed, claudia_zurich, nancy_portland and 23 others
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MaxMetOK
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Jan 15, 2026 at 5:39 AM#30

Reporting back.

Six weeks on from posting: I stopped reading the weekly number and started reading a four-week average, and the "stall" I opened this thread about was a 1.8kg loss I could not see.

48 21PurityPaulOR, MaxMetOK, MounjBrad and 45 others
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