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ForumsCardiovascular OutcomesSOUL trial preliminary data — November 2025 Page 7

SOUL trial preliminary data — November 2025

JenMemphis Sun, Mar 16, 2025 at 2:50 AM 51 replies 2,130 viewsPage 7 of 11
mark_tokyo
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Mar 29, 2025 at 8:34 AM#31
BiostatsBrad said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

35 8pete_manc_UK, anna.melb_AU, mark_tokyo and 32 others
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DebRD_ATL
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Mar 30, 2025 at 4:15 AM#32

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Last edited: Mar 30, 2025 at 8:15 AM
36 9RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 33 others
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fiona_VT
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Mar 30, 2025 at 11:55 PM#33
DebRD_ATL said:
The mechanism and the magnitude are separate questions.

Adding a me-too, because a thread of one person's experience is not much use.

37 10jason_sac26, chris_chi24, tampaLisa73 and 34 others
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adam_van
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Mar 31, 2025 at 7:35 PM#34
DebRD_ATL said:
The mechanism and the magnitude are separate questions.

There is a second half to this that has not been said yet. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

38 11tommy_boulder, hyun_seoul, jim_asheville and 35 others
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raj_cambridge
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Apr 1, 2025 at 3:14 PM#35

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Apr 1, 2025 at 4:14 PM
39 12RickReta_CO, PharmHunterJen, TomTeleRx and 36 others
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