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ForumsCardiovascular OutcomesSELECT cost-effectiveness — need advice Page 4

SELECT cost-effectiveness — need advice

MikeKY_noInsulin Sun, Apr 6, 2025 at 12:56 AM 16 replies 1,703 viewsPage 4 of 4
anna.melb_AU
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Apr 10, 2025 at 5:23 AM#16
EndoResFellow said:
Mendelian randomization evidence supporting GLP-1 pathway modulation for cardiovascular risk: genetic variants in the GLP1R gene region associated…

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

49 22DerekSJ_a1c, paige_pharma, emma_london and 46 others
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LabKate
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Apr 10, 2025 at 8:28 PM#17

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

50 23laura_annarbor, JenMemphis, pat_auckland and 47 others
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DanielChem_CHI
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Apr 11, 2025 at 11:34 AM#18
stefan_berlin said:
Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 →…

Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:

Weight: consistent downtrend, -2.0 lbs/week average
Fasting glucose (finger stick): stable at 83 mg/dL
Blood pressure (home): 115/73 average
Resting heart rate: 63 bpm (down from 79)
Waist circumference: down 13 inches total

The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.

Last edited: Apr 11, 2025 at 1:34 PM
1 24patPC_UT
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PeptideSynthNJ
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Apr 12, 2025 at 2:40 AM#19
stefan_berlin said:
Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 →…
stefan_berlin said:
...cardiovascular risk is just another fad...

I understand the skepticism — we've all seen "miracle" weight loss solutions come and go. But consider what makes GLP-1 agonists different:

  • Phase 3 RCTs with thousands of participants (not 20-person pilot studies)
  • Published in NEJM, JAMA, Lancet (not press releases)
  • Replicated across multiple independent research groups
  • Proven cardiovascular and renal benefits beyond weight loss
  • Biological mechanism fully characterized at the receptor level

This isn't a fad — it's a new drug class supported by the highest level of clinical evidence. The comparison to past fads is understandable but inappropriate.

Last edited: Apr 12, 2025 at 6:40 AM
2 0MikeKY_noInsulin, Dr.RaviCardio
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mike_mod
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Apr 12, 2025 at 5:46 PM#20

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.

24 22PurityPaulOR, MaxMetOK, MounjBrad and 21 others
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