Blood pressure reduction mechanisms on GLP-1 — anyone have experience?

This one has a reasonably settled answer, so here it is. The pharmacokinetics explain nearly every practical question asked here. Albumin binding above 99% slows clearance enough to make weekly dosing possible; a terminal half-life near a week means four to five weeks to steady state and therefore a four-week titration interval; subcutaneous bioavailability around 89% means injection site barely matters. Those three facts answer most timing questions before they are asked.

RetaRick_CA said:

The pharmacokinetics explain nearly every practical question asked here.

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.

bri_stats said:

My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.

This matches mine closely enough to be worth saying so out loud. Nothing to add that would improve it.

From the other side of the consultation, briefly.

6 month update on cardiovascular risk: down 61 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.