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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide body composition: SURMOUNT-1 DEXA substudy data — need advice Page 2

Tirzepatide body composition: SURMOUNT-1 DEXA substudy data — need advice

dave_SLC Sun, Apr 6, 2025 at 2:08 AM 12 replies 1,479 viewsPage 2 of 3
lucas_SP_BR
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Apr 6, 2025 at 7:10 AM#6

Adding the numbers, since they settle part of this. Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with published data behind them are 5, 10 and 15mg.

Last edited: Apr 6, 2025 at 9:10 AM
29 7NurseKim_ATL, paul_denver, TinaHashiRN and 26 others
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MikeNYC_runner
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Apr 6, 2025 at 9:08 AM#7

Following on from PeptideChemSF — and this may be the naive question:

Whether resistance training and protein change the ratio or only the absolute amount?

30 8HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 27 others
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newstart_MO
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Apr 6, 2025 at 11:06 AM#8
lucas_SP_BR said:
Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with…

Adding the part of the answer the thread has not reached. Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five. That matters when you are deciding whether a dose step has finished expressing itself.

31 9HPLC_Greg, LibrarianMeg, bri_stats and 28 others
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dave_SLC
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Apr 6, 2025 at 1:04 PM#9

OP back with an update, since a thread like this is useless without one.

Second scan under matched conditions came back with the lean number nearly a kilogram higher than the first, so a chunk of what I panicked about was hydration. Strength numbers were up throughout.

32 10FranDenver, Dr.BariatricHTX, LindaRN_retired and 29 others
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CarlaRPh_TPA
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Apr 6, 2025 at 10:30 PM#10
newstart_MO said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution. Hydration status moves the lean compartment by a kilogram or more between scans, so any comparison of scans done at different times of day or different hydration states is noise.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Apr 7, 2025 at 2:30 AM
20 20emily_PDX, Dr.SleepRoch, laura_annarbor and 17 others
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