Compounded tirzepatide — looking for input

Dr.NutriCornell said:

Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

Can confirm the pattern Dr.NutriCornell describes. Worth adding the genuine exception, because it is real and narrow: a change made for an identified patient where the prescriber determines it produces a significant clinical difference for that patient. A grid of fixed doses offered to everybody is not that, whatever the intake form says.

dave_SLC said:

One habit that pays for itself: post the method alongside the number.

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

sarah_TO said:

The mechanism and the magnitude are separate questions.

This is my experience too, for whatever a second data point is worth.

Moderator note: the sourcing question belongs in the vendor section and has been split out.