Planning the end of this rather than the middle of it, which nobody around me seems to want to talk about while it is still going well.
The bit I cannot resolve on my own is whether there is a lowest maintenance dose with actual maintenance data behind it, or whether everything published sits at the top of the ladder.
Happy to be told the question itself is wrong.
Short answer first, then the reasoning. One third of STEP 4 participants held most of their loss without the drug, and nobody has convincingly characterised who they are. That subgroup is the most interesting unanswered question in the field and it is routinely flattened into the two-thirds headline.
mike_nyc said:One third of STEP 4 participants held most of their loss without the drug, and nobody has convincingly characterised who they are.
Agreed, and reference ranges are laboratory-specific. Comparing your number to somebody else's range, or to a screenshot from another country, is how people convince themselves something is wrong.
Ask again with the specifics and you will get a better answer than this one.
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View Resultsquinn_sf said:Planning the end of this rather than the middle of it, which nobody around me seems to want to talk about while it is still going well.
Same position here, arrived at the long way round. Extending the interval and reducing the dose are pharmacologically different. Reducing the dose lowers the whole exposure curve evenly; extending the interval keeps the peak and drops the trough. Since the appetite effect tracks the trough, interval extension tends to give you good days and bad days rather than a uniformly smaller effect, which most people find harder to live with.
That is the short version; the long version is somebody else's post.
From the other side of the consultation, briefly.
Pregnancy after maintenance dosing weight loss: stopped GLP-1 medication 3 months before TTC as recommended. Was terrified of regaining weight during pregnancy.
Worked closely with my OB and MFM. Gained 27 lbs during pregnancy (within recommended range). Baby is healthy. The metabolic improvements from pre-pregnancy weight loss gave both of us a healthier pregnancy.
If you're planning pregnancy, discuss the medication discontinuation timeline with your OB. GLP-1 agonists are NOT safe during pregnancy.