My dad had a heart attack and now I am terrified - will GLP-1 help? — looking for input

pat_auckland said:

I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.

Adding a me-too, because a thread of one person's experience is not much use. Posting only so the count is not one.

wendy_avl said:

I want to bring up the cardiovascular angle on cardiovascular risk.

Anti-inflammatory mechanisms of GLP-1 agonists and cardiovascular risk: beyond weight loss, GLP-1R activation directly suppresses NF-κB signaling, reduces NLRP3 inflammasome activation, and decreases monocyte/macrophage adhesion to endothelium[1].

Clinical correlates: hsCRP reduction of 30-60% (consistently seen across trials), reduced carotid intima-media thickness, and decreased coronary plaque inflammation on PET imaging.

These anti-inflammatory effects likely contribute to the cardiovascular benefit seen in SELECT — and may explain benefits beyond what weight loss alone would predict.

wendy_avl said:

I want to bring up the cardiovascular angle on cardiovascular risk.

6 month update on cardiovascular risk: down 51 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.

Following on from wendy_avl — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.