TRIUMPH program trial design overview — all Phase 3 arms

ingrid_STO said:

The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Ask again with the specifics and you will get a better answer than this one.

claudia_zurich said:

Relative and absolute effects need reading together.

Pushing back on claudia_zurich here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

One concrete data point for the thread. A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator. Three questions, and they resolve most disagreements in these threads.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.