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ForumsLab Results & BiomarkersSHBG changes during weight loss on GLP-1 — hormonal implications Page 2

SHBG changes during weight loss on GLP-1 — hormonal implications

Dr.ReproEndo Fri, May 29, 2026 at 2:44 AM 17 replies 420 viewsPage 2 of 4
jason_paloalto
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May 29, 2026 at 7:29 AM#6

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Last edited: May 29, 2026 at 12:29 PM
18 21tane_welly, Dr.PathRoch, mona_PHX and 15 others
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AttorneyGrant
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May 29, 2026 at 9:20 AM#7

One thing that is still open after Dr.PathRoch’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

19 22laura_annarbor, JenMemphis, pat_auckland and 16 others
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NurseAsh_DET
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May 29, 2026 at 11:11 AM#8
jason_paloalto said:
If you are going to change something, change one thing and give it long enough to express itself.

There is a second half to this that has not been said yet. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: May 29, 2026 at 5:11 PM
20 23BrianDallas92, labquiet_amy, emily_PDX and 17 others
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Dr.ReproEndo
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May 29, 2026 at 1:02 PM#9

OP back with an update, since a thread like this is useless without one.

Reporting back with a partial result, because a partial result is still better than silence. Two of the three things suggested helped; I cannot separate them and I am not going to pretend otherwise.

Last edited: May 29, 2026 at 2:02 PM
21 24GraceAZ_72, carl_compliance, DanielChem_CHI and 18 others
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FDA_TrackerJim
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May 29, 2026 at 9:54 PM#10
NurseAsh_DET said:
Start from the measurement rather than the conclusion.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: May 30, 2026 at 12:54 AM
11 11jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 8 others
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