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ForumsTirzepatide (Mounjaro / Zepbound)5mg doing nothing - should I ask to go up? — need advice

5mg doing nothing - should I ask to go up? — need advice

Dr.LeslieOBGYN Tue, Sep 2, 2025 at 12:56 PM 12 replies 1,308 viewsPage 1 of 3
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Dr.LeslieOBGYN
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Sep 2, 2025 at 12:56 PM#1

This is the version of the explanation I wish somebody had given me, written down before I forget what confused me. It is about tirzepatide, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five. That matters when you are deciding whether a dose step has finished expressing itself.

The condition it depends on

The caveat that the head-to-head used semaglutide 1mg, not 2.4mg. It is still the best direct evidence available, but it is not the comparison most people think they are citing.

The practical version

Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with published data behind them are 5, 10 and 15mg.

What I am not sure about

The narrow version of the question is how much of the tirzepatide advantage is the GIP component and how much is simply that the dose ladder goes higher in receptor-occupancy terms. I have searched first, so if this is covered somewhere point me at it and I will read it.

— Dr.LeslieOBGYN · corrections welcome and will be edited into this post with credit
48 1Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 45 others
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NurseKim_ATL
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Atlanta, GA
Sep 2, 2025 at 1:33 PM#2
Dr.LeslieOBGYN said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

No disagreement with Dr.LeslieOBGYN. One condition attached. SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1. Different trials, different populations, so the comparison is indicative rather than decisive — but SURPASS-2 was a genuine head-to-head and it pointed the same way.

49 2raj_cambridge, ingrid_STO, pete_nash and 46 others
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RetaRick_CA
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Sep 2, 2025 at 2:10 PM#3
Dr.LeslieOBGYN said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Pushing back on Dr.LeslieOBGYN here. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.

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ingrid_STO
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Sep 2, 2025 at 2:47 PM#4

Answering the narrow version, because the broad one does not have a single answer. The GIP arm is doing real work rather than padding the label. GIP receptor agonism appears to improve adipose insulin sensitivity and lipid handling, and — counter-intuitively — GIP signalling in the CNS reduces nausea rather than adding to it, which is why tolerability at high total agonism is better than the GLP-1-only comparison would predict. SURPASS-2 is the cleanest head-to-head: tirzepatide beat semaglutide 1mg at every dose tier.

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pete_nash
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Sep 2, 2025 at 6:12 PM#5
NurseKim_ATL said:
SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

Second this. Posting only so the count is not one.

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