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ForumsCompounding & FormulationBacteriostatic water sourcing and sterility considerations — July 2024 Page 7

Bacteriostatic water sourcing and sterility considerations — July 2024

Dr.GastroMayo Tue, Dec 17, 2024 at 10:11 AM 48 replies 2,414 viewsPage 7 of 10
JenMemphis
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Apr 13, 2025 at 1:08 PM#31
Dr.GastroMayo said:
Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality…

Second this. The detail I would add is minor and it is already implied above.

Last edited: Apr 13, 2025 at 6:08 PM
13 13MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 10 others
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sarah.morrison
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Apr 22, 2025 at 7:11 PM#32
Dr.GastroMayo said:
Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality…

There is a second half to this that has not been said yet. The useful checklist is about verifiability rather than presentation. Independent test results commissioned by buyers rather than by the seller, consistency across multiple batches over time rather than one flattering report, a physical address and a company registration that resolve, batch and lot numbers on the actual labelling, and a shipping practice that matches what the material needs. Everything a good-looking website provides is cheap to fake; none of the items above are.

12 12roxy_nash, tony_orlando, Dr.NephBHM_UK and 9 others
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Dr.NateNeph
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May 2, 2025 at 1:19 AM#33
Dr.GastroMayo said:
Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality…

Compounding pharmacy dose accuracy check for dosing arithmetic: I always verify my first dose from a new vial by weighing it on a milligram scale. Draw up your dose, weigh the syringe, subtract empty syringe weight, compare to expected water weight at that volume.

For a 10-unit dose (0.1mL): expected weight ~100mg of water. If it's significantly off, your syringe may be inaccurate. Cheap insulin syringes can have ±5% volume accuracy. Spring for quality brands like BD or Terumo.

11 11SteveThurs, B12Beth, RickReta_CO and 8 others
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HPLC_Greg
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May 11, 2025 at 7:33 AM#34

A narrower follow-up, since the general answer is now clear:

How people are distinguishing a supplier having a bad batch from a supplier on the way out?

10 10Dr.MetabolicMD, RetaRick_CA, JenPlateau and 7 others
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adam_van
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May 20, 2025 at 1:52 PM#35
Dr.NateNeph said:
Compounding pharmacy dose accuracy check for dosing arithmetic: I always verify my first dose from a new vial by weighing it on a milligram scale.

Regarding dosing arithmetic multi-dose vial contamination prevention: after reconstituting, I wipe the vial stopper with a fresh alcohol swab before EVERY single draw. I also never touch the stopper with my fingers and use a new needle for each draw.

Even with bacteriostatic water preservative, contamination is cumulative. One sloppy draw can introduce bacteria that multiply over days. Aseptic technique isn't optional — it's essential for injectable medications.

9 9hyun_seoul, jim_asheville, matt_MKE and 6 others
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