Jun 7, 2026 at 3:28 AM#2
your results are incredible and very consistent with what we're seeing in clinical practice post-FLOW trial. Let me explain the eGFR dip for others:
The initial eGFR dip is actually a GOOD sign. Both GLP-1 RAs and SGLT2 inhibitors reduce intraglomerular pressure (the pressure inside the kidney's filtering units). This initially causes eGFR to drop by 3-8 mL/min because the kidney is filtering less aggressively — but this reduced pressure is what PROTECTS the kidney long-term.
Think of it like a fire hose being turned down from "blast" to "steady stream." Less volume per minute, but much less damage to the delicate filtering membranes.
The FLOW trial showed:
- 24% reduction in kidney disease progression
- 21% reduction in eGFR decline over time
- Significant albuminuria reduction
Your UACR going from 186 to 68 mg/g is the most meaningful number here. You're trending toward the normal range (<30).
11 14LibrarianMeg, bri_stats, pete_manc_UK and 8 others
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