NurseAsh_DET said:Start from the measurement rather than the conclusion.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
RickReta_CO said:Steady state is the thing most people miss.
This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.
NurseAsh_DET said:Start from the measurement rather than the conclusion.
I read this differently from NurseAsh_DET, on substance rather than tone. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsOne concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.