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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025 Page 7

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

LabKate Sat, Mar 14, 2026 at 9:46 PM 36 replies 1,552 viewsPage 7 of 8
lisa_labSD
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Apr 8, 2026 at 12:45 PM#31

Following on from VendorMark — and this may be the naive question:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

18 16stefan_berlin, Dr.EM_Chicago, pete_RVA and 15 others
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RegAffairsDC
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Apr 10, 2026 at 9:26 AM#32
LabKate said:
Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me.

I read this differently from LabKate, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

19 17Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC and 16 others
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PeptideSynthNJ
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Apr 12, 2026 at 6:06 AM#33
LabKate said:
Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

20 18BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 17 others
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hyun_seoul
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Apr 14, 2026 at 2:45 AM#34
LabKate said:
Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me.

Genuinely useful, thank you. I had the facts and not the framework.

21 19BariatricNurseD, MASHdoc_SA, GenomicsKate and 18 others
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Dr.EM_Chicago
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Apr 15, 2026 at 11:23 PM#35

From the other side of the consultation, briefly. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

22 20lisa_labSD, adam_van, Dr.SurgeonPGH and 19 others
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