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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025 Page 4

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

LabKate Sat, Mar 14, 2026 at 9:46 PM 36 replies 1,552 viewsPage 4 of 8
andrew_nyc
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Mar 18, 2026 at 4:41 AM#16

Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Last edited: Mar 18, 2026 at 9:41 AM
11 9Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 8 others
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ben_calgary
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Mar 18, 2026 at 4:53 PM#17
BethLabQueen said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Mar 18, 2026 at 10:53 PM
12 10CanadaChris, ZaraB_AL, JakeSmashed95 and 9 others
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MeganSA_TX
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Mar 19, 2026 at 5:04 AM#18
BethLabQueen said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

13 11JessicaM_2024, TomFromTexas, mike.trainer_LA and 10 others
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Dr.Martinez
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Mar 19, 2026 at 5:15 PM#19

Clinical perspective, offered as context rather than as advice. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

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Admin
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Mar 20, 2026 at 5:26 AM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

36 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 33 others
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