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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirz + walking = the only combo I needed apparently

Tirz + walking = the only combo I needed apparently

wanda_boise Thu, Mar 19, 2026 at 10:58 AM 26 replies 834 viewsPage 1 of 6
wanda_boise
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Mar 19, 2026 at 10:58 AM#1

I trained through the whole thing, three times a week, and the effect on the scale was almost nothing while the effect on everything else was large.

What I actually want to know is what training is actually for during a large deficit, because framing it as calorie burn sets people up to quit when the arithmetic disappoints them.

Not looking for reassurance. Looking for the part I have got wrong.

32 10DanielChem_CHI, marco_milano, pam_columbus and 29 others
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Dr.NateNeph
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Mar 19, 2026 at 11:27 AM#2
wanda_boise said:
I trained through the whole thing, three times a week, and the effect on the scale was almost nothing while the effect on everything else was large.

Exercise-induced nausea amplification with training: I learned the hard way that intense exercise within 36 hours of injection can make nausea much worse. The combination of delayed gastric emptying + exercise-induced blood flow redistribution is rough on the GI system.

My workaround: inject Friday evening, do low-intensity activity Saturday, and save my intense workouts for Tuesday-Thursday when the GI effects have subsided. Timing your training around your injection schedule is a real optimization strategy.

33 11NauseaFreeNow, SteveThurs, B12Beth and 30 others
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traveltech_sara
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Mar 19, 2026 at 11:55 AM#3
Dr.NateNeph said:
Exercise-induced nausea amplification with training: I learned the hard way that intense exercise within 36 hours of injection can make nausea much…

Pet owner bonus of training: my dog is also losing weight because we're walking 2-3x more than before. His vet is thrilled. 🐕

We went from a 15-minute shuffle around the block to 60-minute walks through the neighborhood. He's more energetic, I'm more energetic, and we're both healthier.

Get a dog. Or borrow one. Walking a dog is the best low-impact exercise motivation that exists. They never let you skip a walk. 🐾

34 12wanda_boise, NurseAsh_DET, BenResearch_OR and 31 others
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Dr.EndoEP
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Mar 19, 2026 at 12:24 PM#4
wanda_boise said:
I trained through the whole thing, three times a week, and the effect on the scale was almost nothing while the effect on everything else was large.

Same pattern here, and in the same order. I had assumed I was the exception until I read this.

35 13Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 32 others
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KevinCompounds
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Mar 19, 2026 at 3:08 PM#5

Adding the clinical framing, because it changes how the question reads.

Exercise transformation with training: went from barely able to walk a block to completing a 10K last weekend.

My fitness journey alongside GLP-1 therapy:

  • Month 1-2: Walking 15 min/day
  • Month 3-4: Walking 30-45 min, started bodyweight exercises
  • Month 5-6: Joined a gym, started resistance training
  • Month 7+: Running, lifting heavy, swimming for fun

The weight loss made movement possible. The movement made more weight loss possible. Virtuous cycle in action.

36 14NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 33 others
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