The "Ozempic face" phenomenon — 6 month update

Dr.EndoEP said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at Dr.EndoEP’s question from a different direction. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Happy to go further on any of that.

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

One thing that is still open after Dr.EndoEP’s answer:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

Dr.NateNeph said:

Worth stating the units and the reference range whenever you post a number here.

I read this differently from Dr.NateNeph, on substance rather than tone. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Dr.NateNeph said:

Worth stating the units and the reference range whenever you post a number here.

No disagreement with Dr.NateNeph. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.