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ForumsTirzepatide (Mounjaro / Zepbound)Switching from sema to tirz and WOW the difference Page 5

Switching from sema to tirz and WOW the difference

KarenAZ_mom Wed, Apr 1, 2026 at 8:41 AM 27 replies 1,036 viewsPage 5 of 6
MeganSA_TX
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Apr 16, 2026 at 9:30 PM#21
Dr.PainCLE said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Coming at Dr.PainCLE’s question from a different direction. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Apr 16, 2026 at 11:30 PM
11 11PharmD_Rodriguez, julia.endo, JessicaM_2024 and 8 others
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Dr.GutHealth
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Apr 22, 2026 at 4:40 AM#22

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Apr 22, 2026 at 9:40 AM
10 10tyler_CSCS, VanRx_Mike, steve_okc and 7 others
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DadBodDave
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Apr 27, 2026 at 11:48 AM#23

Following on from Dr.PainCLE — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

9 9pat_auckland, Dr.GastroMayo, JakeBK_lifts and 6 others
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DanielChem_CHI
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May 2, 2026 at 6:52 PM#24
Dr.GutHealth said:
Keep the original post as written when you update it, and add the correction underneath.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

8 8ben_calgary, patPC_UT, Dr.DermMIA and 5 others
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newstart_MO
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May 8, 2026 at 1:53 AM#25
Dr.GutHealth said:
Keep the original post as written when you update it, and add the correction underneath.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

Last edited: May 8, 2026 at 7:53 AM
7 7RunnerRach, TrialNerd_Beth, HPLC_Greg and 4 others
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