Small molecule vs peptide GLP-1 agonists — what worked for you?

Dr.AddMedPHL said:

Oral semaglutide is absorbed in the stomach with the help of SNAC, which locally raises pH and protects the peptide long enough to cross.

I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

sarah.morrison said:

I do not accept that the fasting window is a minor inconvenience.

Coming at sarah.morrison’s question from a different direction. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

One thing that is still open after NeuroNate’s answer:

Whether the fasting requirement is as strict in practice as the label implies, and what people actually see when they get it wrong?

Closing the loop on my own question.

Follow-up: moving the tablet to the moment I wake, before anything else, was the whole fix. The dose never changed.