NurseAsh_DET said:Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…
Same experience, arrived at from the opposite direction.
FDA_TrackerJim said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Pushing back on FDA_TrackerJim here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
FDA_TrackerJim said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.
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View ResultsFDA_TrackerJim said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Genuinely useful, thank you. I had the facts and not the framework.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.