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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-2: tirzepatide for T2DM + obesity — dual indication results Page 4

SURMOUNT-2: tirzepatide for T2DM + obesity — dual indication results

Dr.MetabolicMD Mon, May 25, 2026 at 6:35 AM 18 replies 466 viewsPage 4 of 4
LindaRN_retired
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Jun 2, 2026 at 7:16 PM#16
PharmD_Rodriguez said:
Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

This matches mine closely enough to be worth saying so out loud. Nothing to add that would improve it.

25 0DataDave, Dr.GutHealth, amsterdam_pete and 22 others
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Dr.SurgeonPGH
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Jun 4, 2026 at 1:22 AM#17

A narrower follow-up, since the general answer is now clear:

Why A1C lags the way it does, and what to look at in the meantime if you want to know sooner?

24 24TomTeleRx, DoseLogDan, SleepFixSam and 21 others
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HPLC_Greg
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Jun 5, 2026 at 7:29 AM#18
Dr.PulmRoch said:
One practical note: write down what you did and when, before you need it.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

23 23RetaRick_CA, JenPlateau, SallyK_inj and 20 others
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DoseLogDan
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Jun 6, 2026 at 1:36 PM#19
Dr.PulmRoch said:
One practical note: write down what you did and when, before you need it.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Worth separating that from glycaemic control, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

I would rather be corrected than agreed with, if it comes to it.

22 22sophie_paris, mel_PDX, Dr.AddMedPHL and 19 others
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mike_mod
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Jun 7, 2026 at 7:44 PM#20

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Thread quality here is what the rules are for. Keep it up.

50 0PurityPaulOR, MaxMetOK, MounjBrad and 47 others
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