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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareStarted this morning and already overthinking everything Page 3

Started this morning and already overthinking everything

hannah_MT Sat, Jan 3, 2026 at 12:20 PM 13 replies 1,158 viewsPage 3 of 3
PurityPaulOR
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Jan 6, 2026 at 8:39 AM#11
hans_munich said:
Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Ask again with the specifics and you will get a better answer than this one.

44 19Dr.LeslieOBGYN, MikeNYC_runner and 41 others
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WendyG_ATL
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Jan 8, 2026 at 2:45 AM#12
Dr.BariatricHTX said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

Last edited: Jan 8, 2026 at 3:45 AM
43 18rachel_ABQ, traveltech_sara, AttorneyGrant and 40 others
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FranDenver
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Jan 9, 2026 at 8:51 PM#13
hans_munich said:
Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

I read this differently from hans_munich, on substance rather than tone. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Last edited: Jan 10, 2026 at 2:51 AM
42 17BariatricNurseD, MASHdoc_SA, GenomicsKate and 39 others
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Dr.PulmRoch
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Jan 11, 2026 at 2:58 PM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Jan 11, 2026 at 3:58 PM
41 16DebRD_ATL, KristenIndy, MarkLI_maint and 38 others
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Admin
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Jan 13, 2026 at 9:06 AM#15

Moderator note: a couple of off-topic posts removed. Carry on.

Last edited: Jan 13, 2026 at 1:06 PM
40 15PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 37 others
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