Rybelsus on an empty stomach is ruining my mornings — anyone have experience?

Dr.RenalNash said:

The OASIS programme put 50mg oral in the same territory as 2.4mg injectable — around 15% mean weight loss — but it needed a dose 20 times larger to…

I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

JennaRN said:

I do not accept that the fasting window is a minor inconvenience.

Coming at JennaRN’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

I would rather be corrected than agreed with, if it comes to it.

One thing that is still open after hans_munich’s answer:

How much of the oral variability is the SNAC absorption window and how much is dose, because the two get conflated constantly?

Closing the loop on my own question.

Update — I went back to the injectable. Not because the tablet did not work, but because the fasting window and my mornings were never going to agree.